Background: The most sensitive parameter for evaluation of airway hyper-responsiveness is PC35 (35% decrease in specific airway conductance). But assessment of this parameter requires expensive equipments. This study aimed to evaluate mid expiratory flow and dysanapsis parameters in standard spirometry for possible substitution of PC35.Materials and Methods: Thirty-seven subjects with clinical findings suggestive of asthma who had normal standard spirogram were entered in this case-control prospective study. Thirty- seven healthy volunteers were also included in this study as controls.Airway responsiveness was examined by methacholine challenge test and measurement of PC20 and PC35. In addition, concentration of methacholine needed for 20% reduction in FEF25-75%, MEF50%, and FEF25-75%/FVC was determined and compared with PC35 as the gold standard. FEF25-75%/FVC ratio was used for evaluation of dysanapsis. Results: PC35 was more sensitive than PC20 and was obtained in 93% (68/73) of patients in both groups. Although PC35 and new parameters could be positive in both groups, the concentrations in two groups were significantly different. Regression model showed that in asthmatic patients all the conventional and new parameters had good and comparable correlations with PC35. But in the control group alone and in both asthmatic and control groups, PC20 of FEF25-75%/FVC showed a significant correlation with PC35. PC20 of FEF25-75/FVC was also significantly correlated with PC20 of FEV1 in asthmatic and control groups. PC20 of FEF25-75/FVC and MEF50% revealed the best accuracy. An equation was determined for calculation of PC35 according to PC20 of FEF25-75 /FVC and MEF50% when PC35 was unavailable. Conclusion: PC20 of FEF25-75/FVC ratio and MEF50% are sensitive parameters for diagnosis of airway responsiveness. PC20 of FEF25-75/FVC is the best substitution for PC35.

Background: Opium is an oldest recreational abuse substance with dependency. Small airway diseases (SAD) were established within opium user’s population. Bronchial hyper-responsiveness (BHR) reflects airway reactivity and inflammation. Opium can induce airway inflammation and following airway reactivity.The objective of the study assessed status of BHR among SAD with regular inhaled opium users. It performed with hypertonic normal saline provocation challenge test.Methods: Target population enrolled among SAD with inhaled regular opium users. In the next step, standard hypertonic normal saline provocation test carried out on the sample study.Results: A total of 46 subjects followed the study. The mean age±SD was 50.1±1.2 years, with median 48 years.91% of those were male. A positive result of BHR was distributed more frequently in the chronic obstructive pulmonary disease (COPD) with the asthma phenotype. In addition, it was more market in the youngest and advanced age classes equally.Conclusion: hypertonic normal saline provocation test result was quite noticeable between regular inhaled opium users. BHR was detected more frequently in COPD with asthma phenotype, COPD, chronic bronchitis, and bronchial asthma disease, respectively. The outcome indirectly revealed that there was a relation between airway inflammation and opium inhalation in population. It may be reflected an added effect on the predisposing risk factors of induced airway inflammation and hyper-reactivity of airway in target populations.

Background: Risk factors for the severity of occupational asthma (OA) are often attributed to occupational exposure. However, some recent epidemiological data suggest a link with obesity. The study aimed to analyze the relationship between obesity and the severity of (OA) assessed by non-specific bronchial provocation. Materials and Methods: We conducted an epidemiological descriptive retrospective study including patients who were referred to the Occupational Medicine Department of Farhat Hached University Hospital of Sousse, for (OA) and who have completed a non-specific bronchoprovocation test to metacholine. Results: Our population consisted of 131 cases of (OA) with a female predominance. The average BMI was 27.34 ±5.30 kg. Obesity was observed in 29.8% of cases. The non-specific metacholine bronchial provocation test revealed an average dose of PD20 at 750.4 ±656.3 μg. Severe (OA) was observed in (35.1%). After univariate analysis, obesity in asthmatics had a significant association with age (p<0.001), marital status (p=0.005), average professional seniority (p<0.001), the evolution of complaints (p=0.035) and abnormal initial spirometry (p=0.044). As for the severity of (OA), the univariate analytical study did not show a significant link with obesity (p=0.68). Conclusion: The association between obesity and OA is not an easy task and should be made using more accurate tools to measure body fat percentage. The preventive role of the occupational physician is essential in factories in order to make more prudent decisions when employing workers with a high BMI in high-risk occupations. Hence the importance of regular monitoring of weight in workers exposed to asthmatics during periodic examinations.

The incitement to the murder of the victim due to the provocation and mental agitation of the perpetrator and the subsequent murder deserves to be treated differently. It should be noted that although the excuse of provocation does not have a specific title in the public sector, but from the two articles 38 and 630 of the Islamic Penal Code, which are punishable by imprisonment and murder with retaliation, the perpetrator deserves to be commended and relieved. Responsibility knows and has the following conditions:-Because of the victim's behavior and speech-the physical and direct appearance of the commission –,the original or unintentional of the provocation and the presence of a specific and personal criterion in relation to the criminal conduct and the perpetrator. The present study also examines this issue in Iranian law and jurisprudence, considering the difference in provocation and provocation excitation in criminal law based on the library method.

This is a comparative study of the two victorious revolutions of the Constitutional Iran and the Independence of the USA that lead to the all compassing internal motives of the two oppressed nations to fight against the despotism and oppression and to collapse the ruling political, economic and social order. It is true that the symbols and causes for revolutions are plenty, but this would not prevent from giving a pattern, in which the study of this role in the revolutions would be simplified. As existing despotism and oppression, government's inability to severe and complete depression of revolutionaries, as well as expansion of ideas, such as liberty among them have a fundamental role in providing the necessary and enough objective and subjective grounds for the revolutions, the role played by the rival great powers who were determined to compensate their already losses are influential too. In both these cases, Britain helped the Iranian clergies, merchants and intellectuals to draw Iran peacefully out of its rival (Russian) sphere of influence and France helped the American patriots to change their demand of liberty to a more sustainable one of independence from Britain.

Contact dermatitis is an inflammatory skin disease due to contact with different substances and caused by two mechanisms: allergy and irritation. Contact dermatitis is a common skin disease and the most common occupational dermatosis. Differentiating between allergic and irritant contact dermatitis is essential in the identification of etiologic factor(s) and hence, its control and prognosis. This differentiation can be done only by patch test. Unfortunately, this simple, safe and useful test is always neglected. We review the basics of patch test, the method of performance, reading and interpretation of its results, possible side effects and results of studies done with patch test in different countries.

Producion of efficient antimicrobial drugs against to common human pathogens is one of the most important challenges in the field of medical microbiology. Continuous screening of clinical isolates and survey of antimicrobial resistance pattern is critical.Today, disk diffusion and dilution methods are known as the common antimicrobial susceptibility testing methods. Disk diffusion method does not render dependable results in determination of antimicrobial susceptibility pattern because this method is semi quantitative. MIC determination by microdilution and macrodilution techniques and recent method “E-Test”, have given interpretable results to researchers. Microdilution and macrodilution methods are also time consuming, expensive and error- prone methods. Whereas E-Test method is one of the means by which we will be able to determine susceptibility pattern of known species in low cost and short time. In this survey, constructing and printing of E-Test, coating of antibiotic on O.H.P film and quality control of constructed E-Tests were performed according to M7 A7 CLSI Standard. In this study quality of required materials for E-Test Production were suitable. Evaluation of constructed strips was performed using standard strain of staphylococcus aureus and reproducibly of results was appreciated.

Victimology studies based on the facts of social life indicate the victim precipitated in many of criminal homicide. The punishment of the offender should be determined according to the circumstances of the crime and in proportion to his responsibility. Whereas in the Islamic Penal Code of Iran, victim provocation who sometimes is more guilty than the offender, is allocated to Ta'zir punishments only as one of the mitigating factors. This article in descriptive and analytical study, aims to research the role of effective provocation of the victim in abolition of Qisas, considering the results of victimology knowledge and the necessity of the dynamics of criminal jurisprudence. The results of the analysis of some traditions on the subject of Qisas, such as Sahih Suleiman bin Khaled and Sahih Halabi with a new perspective, indicate the abolition of Qisas due to effective provocation of the victim. According to the findings of this study, it is necessary to add a note to the general conditions of Qisas in Article 301 of the Penal Code that the victim will not have the right of Qisas if he has started the aggression and the provocation.